I think Phoebe Piper and Prue had the best chemistry but now since Prue is gone I think Phoebe and Piper have the best chemistry. For some reason its seem obvious that they arent near as close to Paige as to each other.
Hmm Piper Prue and Phoebe had good chemistry but out of the three Prue and Piper had the best. The scenes they had together in All Hell Breaks Loose were fantastic and so dramatic and sad.